a config from 700+ hour player that balances game settings aground framerate/visibility/quality.
low resolution isn't that bad in risk of rain 2 due to game artstyle easily letting you know where is item and where is a hot lizard that is my nemesis.

NOTE: custom resolutions do not work in fullscreenexclusive, and also set this to read-only to prevent game from changing settings to default values. also, game sometimes likes resetting resolution to default one.
goes into E:\SteamLibrary\steamapps\common\Risk of Rain 2\Risk of Rain 2_Data\Config.